Table 3.
Scientific articles about chemokines as biomarker of CD activity included in the systematic review
| CHEMOKINE | ORIGINAL NAME | RECEPTOR | GENE | ARTICLE | SAMPLES | YEAR | CRITERIA FOR DISEASE ACTIVITY | IS IT A POTENTIAL BIOMARKER? |
|---|---|---|---|---|---|---|---|---|
| CCL2 | MCP-1 | CCR2 | Scya2 | Bourgonje et al./Christophi et al. | Peripheral Blood/Intestinal Mucosa | 2018/2012 | Calprotectin level/Histologic | NO/YES (p<0.05) |
| CCL3 | MIP-1α | CCR1/CCR5 | Scya3 | Bourgonje et al. | Peripheral Blood | 2018 | Calprotectin level | NO |
| CCL4 | MIP-1β | CCR5 | Scya4 | Bourgonje et al. | Peripheral Blood | 2018 | Calprotectin level | NO |
| CCL11 | Eotaxin-1 | CCR3 | Scya11 | Bourgonje et al./Bourgonje et al. | Peripheral Blood/Peripheral Blood | 2018/2019 | Calprotectin level/Endoscopic Index | NO/NO |
| CCL17 | TARC | CCR4 | Scya17 | Bourgonje et al. | Peripheral Blood | 2018 | Calprotectin level | NO |
| CCL20 | LARC/Exodus-1 | CCR6 | Scya20 | Christophi et al. | Peripheral Blood | 2012 | Histologic | YES (p<0.05) |
| CCL22 | MDC | CCR4 | Scya22 | Bourgonje et al. | Peripheral Blood | 2018 | Calprotectin level | NO |
| CCL26 | Eotaxin-3 | CCR3 | Scya26 | Bourgonje et al./Bourgonje et al. | Peripheral Blood | 2018/2019 | Calprotectin level/Endoscopic Index | NO/NO |
| CXCL1 | GROα | CXCR2 | Scyb1 | Hong et al./Leal et al. | Intestinal Mucosa/Intestinal Mucosa | 2017/2014 | Endoscopic Index/Endoscopic Index | YES (p<0.001)/YES (p<0.05) |
| CXCL3 | GRO3, MIP-2β | CXCR2 | Scyb2 | Leal et al. | Intestinal Mucosa | 2014 | Endoscopic Index | YES (p<0.05) |
| CXCL8 | IL-8 | CXCR1 | Scyb8 | Arsenescu et al./Boland et al. | Intestinal Mucosa/Intestinal Mucosa | 2008/2015 | Endoscopic Index/Endoscopic Index | YES (p=0.002)/YES (p<0.05) |
| CXCR2 | Bourgonje et al./Brand et al. | Peripheral Blood/Intestinal Mucosa | 2019/2006 | Endoscopic Index/Endoscopic Index | YES (p<0.05)/YES (p<0.05) | |||
| Bruno et al./Christophi et al. | Intestinal Mucosa/Intestinal Mucosa | 2015/2012 | Endoscopic Index/Histologic | NO/NO | ||||
| Taha et al./Yarur et al. | Urine/Peripheral Blood | 2002/2016 | Clinical Index/Histologic | YES (p=0.001)/NO | ||||
| CXCL10 | IP-10 | CXCR3 | Scyb10 | Boland et al./Bourgonje et al. | Intestinal Mucosa/Peripheral Blood | 2015/2018 | Endoscopic Index/Calprotectin level | YES (p<0.05)/NO |
| Christophi et al./Grip et al. | Intestinal Mucosa/Peripheral Blood | 2012/2009 | Histologic/Calprotectin Level | YES (p<0.05)/NO | ||||
| CX3CL1 | Fractalkine | CX3CR1 | Scyd1 | Brand et al. | Intestinal Mucosa | 2006 | Endoscopic Index | YES (p=0.02) |