Table 4.
Scientific articles about adipokines as biomarker of CD activity included in the systematic review
| ADIPOKINE | ARTICLE | SAMPLES | YEAR | CRITERIA FOR DISEASE ACTIVITY | IS IT A POTENTIAL BIOMARKER? |
|---|---|---|---|---|---|
| ADIPONECTIN | Karahman et al./Karmiris et al./Karmiris et al./ | Peripheral Blood/Peripheral Blood/Peripheral Blood/ | 2017/2007/2006 | Clinical Index/Clinical Index/Clinical Index/ | NO/NO/NO |
| Rodrigues et al./Theocharidou et al. | Mesenteric Biopsies/Peripheral Blood | 2012/2016 | Endoscopic Index/Clinical Index | YES (p<0.01)/NO | |
| LEPTIN | Karahman et al./Karmiris et al./Karmiris et al. | Peripheral Blood/Peripheral Blood/Peripheral Blood/ | 2017/2007/2006 | Clinical Index/Clinical Index/Clinical Index/ | NO/NO/NO |
| Rodrigues et al./Trejo-Vazquez et al. | Mesenteric Biopsies/Peripheral Blood | 2012/2017 | Endoscopic Index/Endoscopic Index | NO/YES (p<0.001) | |
| OMENTIN-1 | Yin et al. | Peripheral Blood | 2014 | Clinical Index | YES (p=0.012) |
| PAI-1 | Trejo-Vazquez et al. | Peripheral Blood | 2017 | Endoscopic Index | NO |
| RESISTIN | Karmiris et al./Karmiris et al./Konrad et al. | Peripheral Blood/Peripheral Blood/Peripheral Blood/ | 2007/2006/2007 | Clinical Index/Clinical Index/Clinical Index/ | YES (p=0.004)/NO/YES (p=0.02) |
| Theocharidou et al./Trejo-Vazquez et al. | Peripheral Blood/Peripheral Blood | 2016/2017 | Clinical Index/Endoscopic Index | YES (p=0.014)/NO | |
| VISFATIN | Trejo-Vazquez et al. | Peripheral Blood | 2007 | Endoscopic Index | NO |
| GHRELIN | Karmiris et al./Trejo-Vazquez et al. | Peripheral Blood/Peripheral Blood | 2006/2017 | Clinical Index/Endoscopic Index | NO/NO |
| IL-6 | Boland et al./Bourgonje et al. | Intestinal Mucosa/Peripheral Blood | 2015/2017 | Endoscopic Index/Calprotectin Level | YES (p<0.05)/YES (p<0.01) |
| Bourgonje et al./Christophi et al. | Peripheral Blood/Intestinal Mucosa | 2019/2012 | Endoscopic Index/Histologic Endoscopic | YES (p<0.05)/YES (p<0.05) | |
| Leal et al./Yarur et al. | Intestinal Mucosa/Peripheral Blood | 2014/2016 | Index/Histologic | YES (p<0.05)/YES (p=0.004) | |
| TNF-α | Boland et al./Bourgonje et al. | Intestinal Mucosa/Peripheral Blood | 2015/2019 | Endoscopic Index/Endoscopic Index | YES (p<0.05)/YES (p<0.05) |
| Christophi et al./Yarur et al. | Intestinal Mucosa/Peripheral Blood | 2012/2016 | Histologic/Histologic | YES (p<0.05)/YES (p<0.002) |