CircLRP6/miR-545-3p/HMGA1 axis participated in the HG induced VSMCs proliferation, migration, and invasion. (A and B) After co-transfection with si-circLRP6 and miR-545-3p inhibitor, VSMCs were subjected to the detection of HMGA1 mRNA and protein. The treated VSMCs were also subjected to the assessment of proliferation (C and D), migration (E), and invasion (F).