miR590-5p was predicted to bind with the FGF18 transcripts. A: Four different algorithms, including mitarget scan, mirDIP, microRNA.org, and miRDB were used to predict FGF18 mRNA-binding miRNA candidates; B: miR-590-5p was assayed by qPCR after IL-1β treatment for 24 h in human chondrocytes; C: The binding sites between miR-590-5p and the 3’UTR region of FGF18 predicted by PITA/miRanda. ***P < 0.001 versus control; ##P < 0.01, 10 ng/mL versus 30 ng/mL.