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. 2021 Aug 15;13(8):8728–8741.

Figure 6.

Figure 6

miR-590-5p regulated cartilage degeneration related biomarkers in IL-1β-induced chondrocytes. Chondrocytes were treated with 10 ng/mL IL-1β, and then transfected with NC or miR590-5p mimics (100 nM) for 24 h. The mRNA (A) and protein (B) levels of ADAMTs5 and collagen II were detected by qPCR and Western blot. Then, human chondrocytes were treated with 10 ng/mL IL-1β, and then transfected with NC or miR590-5p inhibitors (100 nM) for 24 h. qPCR and Western blot were conducted to determine the mRNA (C) and protein (D) levels of ADAMTs5 and collagen II. *P < 0.05, **P < 0.01 and ***P < 0.001; #P < 0.05, ##P < 0.01 and ###P < 0.001, IL-1β+ mimics or inhibitors versus IL-1β+ NC.