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. 2021 Aug 27;12:721258. doi: 10.3389/fgene.2021.721258

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Copyright © 2021 Li, Wang, Zhang, Qiao, Xia, Kong, Zhao and Yin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Screening of hub genes and functional analysis. (A) Twenty-one differentially expressed genes (DEGs) intersected between the cartilage samples and the synovial membrane samples. (B) Protein–protein interaction (PPI) network of the 21 DEGs and two hub genes screened by the degree method (degree > 4) using cytoHubba. A higher ranking is represented by a redder color. (C) MMP9 and COL3A1 interacting genes indicated using Funrich software. (D) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of MMP9 and COL3A1 interacting genes.