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. 2021 Aug 27;11:720400. doi: 10.3389/fonc.2021.720400

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Copyright © 2021 Zhou, Bai, Long, Hu and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression and clinical value of hub genes. (A) The expression patterns of one TF hubs (ZBTB37) and three lncRNA hubs (CTD-2600H12, NPTN-IT1, and RP11-173A16) with the highest degrees in TCGA LUAD cohorts. (B) Three hub genes (RP11-173A16, RP11-516C1, and ZBTB37) were selected to detect their expression in different stages of lung adenocarcinoma. (C) The prognostic effect of hub lncRNA RP11-173A16 in TCGA cohorts. (D) The prognostic effects of hub lncRNA RP11-173A16 in other two independent validation cohorts. *represents p < 0.05, tumor vs control group http://pathwax.sbc.su.se.