Table 2.
Antibody titers in BALB/c mice after double dose of rF1V vaccination.
| Vaccine Treatmenta | No. Survivors after Challenge | Antibody Titerb , c | Ratio IgG2a/IgG1 | |||
|---|---|---|---|---|---|---|
| Y. pestis CO92 | Y. pestis C12 | IgG | IgG1 | IgG2a | ||
| PBS | 0/10 | 0/10 | 50 (1.00) | 50 (1.00) | 50 (1.00) | 1.0000 |
| 0.5 μg rF1V | 10/10 | 5/10 | 357,771 (1.19) | 1,510,199 (1.14) | 1,789 (1.19) | 0.0012 |
| 1.0 μg rF1V | 10/10 | 8/10 | 476,624 (1.37) | 4,507,631 (1.12) | 5,350 (1.38) | 0.0012 |
| 3.0 μg rF1V | 10/10 | 8/10 | 1,269,921 (1.10) | 2,015,874 (1.19) | 31,874 (1.14) | 0.0158 |
a
Two subcutaneous vaccinations.
b
n was 4 for each group of mice.
c
Antibody titer 28 days after vaccination. Reported as geometric mean (Geo Mean) with geometric standard error (GSE).