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The response of KFBs to the ADSC-CM. ADSC-CM activates the AA-COX-2/PGE2 cascade to inhibit proliferation and initiate the apoptosis of keloid-derived fibroblasts, while the specific COX-2 inhibitors can block this process. AA arachidonic acid, ADSC-CM conditioned medium of adipose-derived stem cells, COX-2 cyclooxygenase-2, DMEM Dulbecco’s modified Eagle’s medium, KFBs keloid dermis-derived fibroblasts, PGE2 prostaglandin E2
