Figure 3.

Effects of SB203580, PD98059 and KN-93 on contractile responses to PE in aortas and MAs treated with DMSO, PugNAc or ST045849. Vessels were treated under AON and AIH conditions or isolated from CON and CIH group rats. The groups were as follows: i) AON, 3-h normoxia treatment; ii) AIH, 3-h intermittent hypxia treatment; iii) CON, normoxic (21% O₂) condition; and iv) CIH, intermittent hypoxia cycles (6–8% O₂ for 2 min and 21% O₂ for another 2 min). Data are presented as the mean ± SD (n=5). *P<0.05. PE, phenylephrine; AIH, acute intermittent hypoxic; CON, control; CIH, chronic intermittent hypoxia; MA, mesenteric artery.