Figure 4.

Effects of SB203580, PD98059 and KN-93 on contractile responses to Ang II. Contractile responses to Ang II during AON and AIH exposure in (A) aortic rings and (B) MAs treated with DMSO, PugNAc or ST045849. Ang II-induced contraction of vessels from CON and CIH rats in (C) aortic rings and (D) MAs treated with DMSO, PugNAc or ST045849. The groups were as follows: i) AON, 3-h normoxia treatment; ii) AIH, 3-h intermittent hypxia treatment; iii) CON, normoxic (21% O₂) condition; and iv) CIH, intermittent hypoxia cycles (6–8% O₂ for 2 min and 21% O₂ for another 2 min). Data are presented as the mean ± SD (n=5). *P<0.05. Ang II, angiotensin II; AIH, acute intermittent hypoxia; CON, control; CIH, chronic intermittent hypoxia; MA, mesenteric artery.