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. 2021 Aug 27;15:727060. doi: 10.3389/fnins.2021.727060

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Copyright © 2021 Anand, Ende, Singh, Qureshi, Duong and Mehler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Accelerated evolution of human brain and SARS-CoV-2: potential mechanisms underlying systemic dyshomeostasis. Evolutionary adaptations mediating innovations in human brain form and function (upper panel). Parallel evolutionary adaptations in SARS-CoV-2 (lower panel). Created using biorender.com. A, Adenosine; I, inosine; ADAR, adenosine deaminases acting on RNA; oSVZ, outer subventricular zone; TF, transcription factor; ORF, open reading frame; RdRp, RNA-dependent RNA-polymerase; E, envelope protein; N, nucleocapsid protein.