. 2021 Aug 27;12:666447. doi: 10.3389/fimmu.2021.666447

Table 3.

Frequencies of T cells and Tregs stratified to subgroups.

Markers for Treg detection	All sepsis workups (n = 51)	No causative pathogen (n = 12)	Viral infection (n = 14)	IBI (n = 25)	Controls (n = 30)
CD3⁺ (%)	59.7 [46.1 – 66.1]	58.4 [43.9 – 64.8]	60.4 [44.9 – 66.3]	61.0 [50.3 – 68.0]	59.1 [55.6 – 64.0]
CD4⁺ (%)	43.7 [36.1– 51.1]	41.4 [35.8 – 47.5]	47.6 [37.6 – 52.6]	44.7 [33.0 – 54.4]	44.0 [35.8 – 47.0]
CD4⁺CD25⁺ (%)	9.5 [7.4 – 11.0]	10.1 [8.5 – 11.6]	9.9 [7.7 – 11.6]	7.5 [6.4 – 9.5]	9.3 [7.8 – 10.1]
CD4⁺CD25⁺ (%)	9.5 [7.4 – 11.0]	10.1 [8.5 – 11.6]	9.9 [7.7 – 11.6]	p = 0.009*	9.3 [7.8 – 10.1]
CD4⁺FoxP3⁺ (%)	5.6 [4.6 – 7.3]	6.4 [4.4 – 8.0]	5.7 [5.3 – 7.7]	5.4 [4.1 – 6.6]	6.4 [5.8 – 7.4]
CD4⁺FoxP3⁺ (%)	p = 0.009*	6.4 [4.4 – 8.0]	5.7 [5.3 – 7.7]	p = 0.007*	6.4 [5.8 – 7.4]
CD4⁺FoxP3⁺CD25⁺Tregs (%)	7.4 [5.9 – 8.0]	7.7 [6.7 – 8.8]	7.4 [6.2 – 8.1]	6.4 [5.1 – 7.7]	7.7 [6.7 – 8.8]
CD4⁺FoxP3⁺CD25⁺Tregs (%)	7.4 [5.9 – 8.0]	7.7 [6.7 – 8.8]	7.4 [6.2 – 8.1]	p = 0.02*	7.7 [6.7 – 8.8]

Data are expressed by percentages and [IQR]. IBI, invasive bacterial infection; p-values were derived from Dunn’s multiple comparisons test (*) and demonstrate the significance between particular subgroup and control group.