Table 4.
Lymphocyte subsets and immune cell count of study cohort and subgroups.
| Number, n | Suspected LOS | IBI | Viral infection | No causative pathogen | Control group |
|---|---|---|---|---|---|
| n=51 | n=25 | n=14 | n=12 | n=22 | |
| White blood cells, cells/nl (median, IQR) | 11.2 (8.3 – 15.5) | 12.6 (7.8 – 16.6) | 11.1 (8.7 – 14.4) | 10.5 (7.9 – 15.1) | 10.1 (7.8 – 12.1) |
| Lymphocytes, cells/nl (median, IQR) | 5.5 (3.7 – 7.1) | 4.4 (3.5 – 6.7) | 7.2 (2.8 – 8.2) | 6.1 (3.9 – 7.4) | 5.7 (4.5 – 7.0) |
| Number, n | n=45 | n=23 | n=14 | n=8 | n=22 |
| CD3+ | 3.5 (2.6 – 4.8) | 3.5 (2.7 – 4.9) | 4.6 (2.9 – 4.9) | 2.7 (0.9 – 4.2) | 3.3 (2.9 – 4.3) |
| CD4+ | 2.7 (1.9 – 3.9) | 2.6 (1.9 – 3.9) | 2.9 (2.4 – 3.9) | 1.9 (0.6 – 3.2) | 2.5 (1.9 – 3.0) |
| CD8+ | 0.8 (0.5 – 1.1) | 0.8 (0.6 – 1.0) | 0.9 (0.5 – 1.4) | 0.7 (0.2 – 1.0) | 0.9 (0.6 – 1.0) |
| CD19+ | 1.0 (0.6 – 1.3) | 0.8 (0.5 – 1.3) | 1.2 (0.7 – 1.4) | 0.9 (1.6 – 1.6) | 1.0 (0.5 – 1.3) |
| (CD16+56) + | 0.4 (0.2 – 0.8) | 0.3 (0.2 – 0.6) | 0.7 (0.4 – 1.0) | 0.5 (0.2 – 0.6) | 0.4 (0.3 – 0.6) |
| p(V)= 0.01 | |||||
| CD4/CD8-ratio | 3.4 (2.6 – 4.5) | 3.4 (2.6 – 4.5) | 4.0 (3.0 – 4.6) | 3.0 (2.6 – 5.7) | 2.8 (2.3 – 2.7) |
| p(C) = 0.03 | |||||
| activated T-lymphocyte | 0.06 (0.03 – 0.1) | 0.06 (0.03 – 0.1) | 0.08 (0.04 – 0.1) | 0.03 (0.03 – 0.08) | 0.03 (0.02 – 0.05) |
| p(C) = 0.04 | p(C) = 0.04 | p(C) = 0.03 |
IBI, invasive bacterial infection; IQR interquartile range; LOS, late-onset sepsis.
p-values were derived from Dunn’s multiple comparisons test; p(V) p-value when compared to subgroup with viral infection; p(C) p-value when compared to control group.