Table 1.
Monocyte proportion changes in CVD.
| Reference | Patient Population | N= | Classical (CM%) | Intermediate (IM%) | Nonclassical (NCM%) | Other Outcomes |
|---|---|---|---|---|---|---|
| Tallone [31] |
CAD (Stable) |
13 | 82 (↓) * | 3.6(=) | 9.2(↑) * | Additionally reported a fourth population, “CD14-CD16+” but not significantly different between groups |
| Control | 14 | 87 | 3.3 | 5.8 | ||
| Dopheide [32] |
PAD (CLI) | 60 | 66.2 (↓) *** | 10.6(↑) *** | 15 (=) | |
| PAD (IC) | 74.4 (↓) * | 10.5 (↑) *** | 23.3 (↑) *** | |||
| Control | 30 | 82 | 6 | 11.9 | ||
| Ozaki [24] |
CAD (multi vessel) |
51 | Not stated | 25.5 (↑) *** | Not stated | |
| CAD (one vessel) |
47 | Not stated | 12.5(↑) ** | Not stated | ||
| Control | 27 | Not stated | 8.5 | Not stated | ||
| Tapp [33] |
CAD (Stable) |
40 | 82 (=) | 6.9 (=) | 10.8 (=) | Additionally included data on STEMI, ↑ IM% and ↓ NCM% vs. control and CAD |
| Control | 40 | 83 | 6.4 | 10.6 | ||
| Shantsila [20] |
CAD (Stable) |
53 | 85 (=) | 5.4 (=) | 9.8 (=) | Proportions calculated from subset counts |
| Control | 50 | 84 | 5.8 | 9.8 | ||
| Sturhan [34] |
CAD (Stable) |
80 | 82 (↓) * | 13 (↑) * | 5 (↑) * | Additionally included data for acute MI, which showed the same changes as CAD vs. control but no difference from CAD group |
| Control | 34 | 90 | 7 | 3 | ||
| Shirai [35] |
CAD | 69 (↓) ** | 20 (↑) ** | 3.5(=) | ||
| Control | 83 | 7 | 4 | |||
| Zhuang [36] |
Unstable angina | 48 | 82(=) | 10.6 (↑) * | 6.97(↓) * | Additionally presented data on STEMI, which showed elevated IM% and lower NCM% vs. controls (p < 0.05) |
| Control | 33 | 82 | 7.4 | 10.3 | ||
| Williams [37] |
CVD (carotid endarterectomy and/or PAD) | 31 | ~88(=) | ~5(↑)* | ~6(=) | Proportions estimated from graph |
| Control | 33 | ~90 | ~4 | ~5 | ||
| Brown [38] |
Diffuse CAD | 50 | 84.5(=) | 7.2(=) | 8.3 (=) | Control had CAD risk factors, as opposed to “healthy control” group |
| Focal CAD | 40 | 85.2(=) | 6.2(=) | 8.6(=) | ||
| Control | 50 | 87.1 | 5.1 | 7.8 | ||
| Eligini [39] |
CAD | 90 | 85.8(=) | 10.5 (↑) *** | 3.7(=) | |
| Control | 25 | 85.1 | 7.6 | 4.6 |
Notes: * p < 0.05 vs. controls, ** p < 0.01 vs. controls *** p < 0.001 vs. controls. Abbreviations: CLI, critical limb ischemia, IC, intermittent claudication.