Table 3.
Candidate genes and loci associated with schizophrenia in cytogenetic, linkage, and genome wide association studies.
| Genomic Region and Candidate Loci |
Gene | Protein |
|---|---|---|
| Vulnerability genes for schizophrenia based on cytogenetic studies | ||
| t (1 ; 11) (q42.1; q14.3) | DISC1 | Disrupted in schizophrenia 1 or DISC1 |
| 22q11.21 Deletion | COMT | Catechol O-methyltransferase |
| Candidate genes for schizophrenia supported by linkage findings | ||
| 1q23.3 |
NOS1AP
RGS4 |
Carboxyl-terminal PDZ-bonding domain of neuronal nitric oxide synthase 1 adaptor protein Regulator of G-protein signaling 4 |
| 6p22.3 | DTNBP1 | Dystrobrev in binding protein 1 |
| 8p12 | NRG1 | Neuregulin 1 |
| 13q33.2; 13q34 | DAOA | D-amino acid oxidase activator |
| Single Nucleotide Polymorphism (SNP) supported by genome wide association studies (GWAS) | ||
| 11q23.2 | DRD2 | Dopamine receptor D2 |
| 7q21.11-q21.12 | GRM3 | Glutamate metabotropic receptor 3 |
| 16p13.2 | GRIN2A | Glutamate ionotropic receptor NMDA type subunit 2A |
| 17p13.3 | SRR | Serine Racemase |
| 5q33.2 | GRIA1 | Glutamate ionotropic receptor AMPA type subunit 1 |
| 12p13.33 | CACNA1C | Calcium voltage-gated channel subunit alpha 1 C |
| 10p12.33-p12.31 | CACNB2 | Calcium voltage-gated channel auxiliary subunit beta 2 |
| 22q13.1 | CACNA1l | Calcium voltage-gated channel subunit alpha 1 l |