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. 2021 Sep 1;22(17):9516. doi: 10.3390/ijms22179516

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A model for the role of locally high 1,25(OH)₂D concentrations in intestinal stem cells’ regenerative function. Inflammation- and gut-homing macrophages were engineered to overexpress the 1α-hydroxylase (MAC-CYP cells). When injected into inflammatory bowel disease patients’ peritoneal cavity, the MAC-CYP cells migrate specifically into inflamed intestines. Subsequently, the MAC-CYP cells de novo produce locally high 1,25(OH)₂D concentrations to enhance intestinal stem cells’ migration and differentiation, thereby augmenting intestinal epithelial repair.