Table 3.
Genotypic distribution of polymorphisms in villages, Sawré Muybu Indigenous Land, Pará, Amazon, Brazil, 2019.
| Gene/SNP | Village | n * | Genotypic Distribution n (%) |
p-Value ** | ||
|---|---|---|---|---|---|---|
| TNF-α (Chromossome 6) | ||||||
| rs1799964 | TT | TC | CC | |||
| Poxo Muybu | 61 | 56 (91.8) | 4 (6.6) | 1 (1.6) | 0.008 | |
| Sawre Aboy | 40 | 25 (62.5) | 13 (32.5) | 2 (5.0) | ||
| Sawre Muybu | 97 | 70 (72.1) | 25 (25.8) | 2 (2.1) | ||
| rs1799724 | CC | CT | TT | |||
| Poxo Muybu | 62 | 31 (50.0) | 27 (43.5) | 4 (6.5) | 0.34 | |
| Sawre Aboy | 40 | 15 (37.5) | 24 (60.0) | 1 (2.5) | ||
| Sawre Muybu | 97 | 50 (51.5) | 40 (41.3) | 7 (7.2) | ||
| rs1800629 | GG | GA | AA | |||
| Poxo Muybu | 56 | 56 (100) | 0 | 0 | 0.050 | |
| Sawre Aboy | 40 | 39 (97.5) | 1 (2.5) | 0 | ||
| Sawre Muybu | 97 | 89 (91.8) | 8 (8.2) | 0 | ||
| IL6 (Chromosome 7) | ||||||
| rs1800795 | GG | GC | CC | |||
| Poxo Muybu | 62 | 62 (100) | 0 | 0 | 0.59 | |
| Sawre Aboy | 40 | 40 (100) | 0 | 0 | ||
| Sawre Muybu | 97 | 96 (99.0) | 1 (1.0) | 0 | ||
| ALAD (Chromosome 9) | ||||||
| rs1800435 | CC | CG | GG | |||
| Poxo Muybu | 56 | 56 (100) | 0 | 0 | 0.36 | |
| Sawre Aboy | 40 | 40 (100) | 0 | 0 | ||
| Sawre Muybu | 96 | 94 (97.9) | 2 (2.1) | 0 | ||
| GSTP1 (Chromosome 11) | ||||||
| rs1695 | AA | AG | GG | |||
| Poxo Muybu | 62 | 37 (59.7) | 24 (38.7) | 1 (1.6) | <0.0001 | |
| Sawre Aboy | 40 | 30 (75.0) | 10 (25.0) | 0 | ||
| Sawre Muybu | 97 | 13 (13.4) | 61 (62.9) | 23 (23.7) | ||
| VDR (Chromosome 12) | ||||||
| rs2228570 | CC | CT | TT | |||
| Poxo Muybu | 62 | 27 (43.5) | 29 (46.8) | 6 (9.7) | 0.01 | |
| Sawre Aboy | 40 | 9 (22.5) | 22 (55) | 9 (22.5) | ||
| Sawre Muybu | 97 | 49 (50.5) | 41 (42.3) | 7 (7.2) | ||
| MMP2 (Chromosome 16) | ||||||
| rs2285053 | CC | CT | TT | |||
| Poxo Muybu | 62 | 58 (93.5) | 4 (6.5) | 0 | <0.0001 | |
| Sawre Aboy | 40 | 34 (85.0) | 6 (15.0) | 0 | ||
| Sawre Muybu | 96 | 58 (60.4) | 37 (38.5) | 1 (1.1) | ||
* n is the number of examined samples of the participants for each polymorphism. Differences in sample sizes are due to available data from PCR amplification for each polymorphism. ** p-value from Chi-square test (Pearson p-value) or Fisher’s exact test.