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. 2021 Sep 2;22(17):9552. doi: 10.3390/ijms22179552

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Graphical representation of modified cytosine and uracil at the C5 position; (b) structures of i-motif and Triplex; (c) CD spectra of i-motif-containing modified cytosine at different pH indicated by different colors, from ref. [203]; (d) comparison of CD spectra between duplex (solid), triplex (dashed dot), and triplex-forming oligonucleotides (TFO, dashed) containing modified sequence at pH 6 from ref. [212]. Copyright (2015) John Wiley and Sons, Inc., and (2004) Oxford University.