Table 3.

Current complete or active acupuncture clinical trials for chemotherapy-induced peripheral neuropathy (CIPN).

Study Title	Identifier	Sponsor	Phase	Chemotherapeutics	Cancer Type	Intervention
Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer	NCT04505553	University of Washington	Phase 2 Pilot Study	Oxaliplatin-Based Chemotherapy	Gastrointestinal Cancer	Oral cryotherapy vs. oral cryotherapy plus acupuncture/acupressure
Acupuncture in Reducing Chemotherapy-Induced Peripheral Neuropathy in Participants With Stage I-III Breast Cancer	NCT03505671	Wake Forest University Health Sciences	NA	NS	Breast Cancer	Acupuncture vs. standard care
Acupuncture for Peripheral Neuropathy Induced by Paclitaxel in Early Stage Breast Cancer	NCT04461977	Instituto Brasileiro de Controle do Cancer	NA	NS	Breast cancer (stages I, II, III)	Acupuncture vs. sham acupuncture
Acupuncture for CIPN in Breast Cancer Patients	NCT02615678	Southern California University of Health Sciences	NA	NS	Breast Cancer	Before and after acupuncture
Integrative Medicine for Chemotherapy-Induced Peripheral Neuropathy	NCT03290976	The Chaim Sheba Medical Center	NA	Taxanes	1. Female patients with breast or gynecological cancers	Single vs. multi-modality acupuncture vs. standard care
Integrative Medicine for Chemotherapy-Induced Peripheral Neuropathy	NCT03290976	The Chaim Sheba Medical Center	NA	NS	2. Patients of either gender with hematological malignancies	Single vs. multi-modality acupuncture vs. standard care
Standard Care Alone or With Acupuncture for CIPN in Breast Cancer and Multiple Myeloma (ACUFOCIN)	NCT02275403	The Christie NHS Foundation Trust	Phase 2	NS	Breast cancer, multiple myeloma, gastrointestinal cancer, or gynecological cancer	Acupuncture vs. standard care
The Use of Acupuncture for Treatment of Chemotherapy-induced Peripheral Neuropathy (CIPN)	NCT02309164	University of Sao Paulo	NA	NS	NS	Acupuncture vs. standard care
Evaluation of the Efficacy of Acupuncture in Chemotherapy-Induced Peripheral Neuropathy	NCT03626220	China Medical University Hospital	NA	NS	Breast cancer	Acupuncture vs. sham acupuncture
The Effectiveness and Cost-Effectiveness of Acupuncture in Managing Chemotherapy-induced Peripheral Neuropathy	NCT02553863	The Hong Kong Polytechnic University	NA	NS	Lung, breast, gynecological, or head & neck cancers, or colorectal cancer (stage I, II, III).	Acupuncture vs. standard care
Efficacy of Acupuncture on Chemotherapy-Induced Peripheral Neuropathy	NCT04739631	Taipei Veterans General Hospital, Taiwan	NA	Taxanes (paclitaxel or docetaxel), platinum (cisplatin, oxaliplatin, carboplatin)	NS	Acupuncture vs. sham acupuncture
Testing the Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Chemotherapy-Induced Peripheral Neuropathy (CIPN)	NCT04367480	University of Rochester NCORP Research Base	NA	NS	NS	TENS
Feasibility Study for Electroacupuncture for Chemotherapy- Induced Peripheral Neuropathy (CIPN)	NCT04092764	H. Lee Moffitt Cancer Center and Research Institute	NA	Taxanes or Platinum-Based	NS	Electroacupuncture vs. NeuroMetrix vs. Rydel-Seiffer tuning fork
Acupuncture for Chemotherapy-induced Peripheral Neuropathy	NCT03582423	Hong Kong Baptist University	NA	Eight cycles of adjuvant oxaliplatin-based chemotherapy	Stage II–III colorectal cancer	Electroacupuncture vs. sham acupuncture
Scrambler Therapy in the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy	NCT02111174	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	NA	NS	NS	Scrambler therapy vs. sham therapy

Abbreviations: NA, not applicable; NS, not specified; TENS, Transcutaneous Electrical Nerve Stimulation.