Table 1.
Effects of melatonin (MEL), ketamine (KET) and MEL/KET combination acute treatments on the open field test.
| Treatment (mg/Kg) 1 | Counts Number | Rearings Number |
|---|---|---|
| Control | 36.87 ± 3.76 | 30.75 ± 2.57 |
| KET 1.5 | 40.12 ± 3.23 | 28.62 ± 3.15 |
| KET 3 | 45.25 ± 4.29 | 28.25 ± 2.66 |
| KET 10 | 56.62 ± 4.36 ** | 45.25 ± 2.85 ** |
| KET 20 | 56.00 ± 3.62 ** | 45.50 ± 3.70 ** |
| KET 30 | 60.12 ± 1.60 *** | 45.37 ± 1.71 *** |
| F(5,47) = 7.260, p < 0.001 | F(5,47) = 9.797, p ≤ 0.001 | |
| Control | 43.87 ± 4.42 | 34.50 ± 3.95 |
| KET 1.5/MEL 4 | 40.11 ± 3.61 | 26.66 ± 2.21 |
| KET 1.5/MEL 16 | 40.90 ± 3.60 | 27.30 ± 3.03 |
| F(2,26) = 0.248, p = 0.783 | F(2,26) = 1.859, p = 0.178 |
1 Data are expressed as the mean ± standard error of the mean (SEM) of independent determinations with 8 to 10 mice per group. Differences between groups were analyzed using a one-way ANOVA, followed by Dunnett’s post-test. ** p ≤ 0.01, *** p ≤ 0.001 when compared with the vehicle control group.