Table 2.
Effects of melatonin (MEL), ketamine (KET) and MEL/KET combination treatments in mice following the triple administration protocol on the open field test.
| Treatment (mg/Kg) 1 | Counts Number | Rearings Number |
|---|---|---|
| Control | 41.12 ± 4.71 | 25.37 ± 2.18 |
| MEL4 | 47.20 ± 5.20 | 29.11 ± 2.16 |
| MEL 16 | 42.62 ± 5.97 | 26.37 ± 4.60 |
| KET 1.5 | 41.40 ± 3.97 | 28.00 ± 2.53 |
| F(3,35) = 0.279, p = 0.840 | F(5,33) = 0.865, p = 0.470 | |
| Control | 43.37 ± 4.71 | 33.25 ± 2.72 |
| KET 1.5/ MEL 4 | 36.87 ± 3.03 | 28.37 ± 3.25 |
| KET 1.5 /MEL 16 | 37.00 ± 5.56 | 26.75 ± 3.22 |
| F(2,23) = 0.664, p = 0.525 | F(2,23) = 1.210, p = 0.318 |
1 Data are expressed as the mean ± standard error of the mean (SEM) of independent determinations with 8 to 10 mice per group. Differences between groups were analyzed using a one-way ANOVA, followed by the Dunnett´s post-test.