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. 2021 Aug 31;22(17):9485. doi: 10.3390/ijms22179485

Figure 1.

Figure 1

Figure 1

Acute β-PEA administration significantly increased circling and head-twitching behavior in mice. (A) Experimental timeline for open-field test. (B) Representative circling patterns (black lines in each gray rectangle) 5–10 min after acute administration of saline or β-PEA. (C,E,G) Total number of circling (C), head-twitching response (E), and distance traveled (G) 30 min after acute saline or β-PEA administration. (D,F,H) Temporal changes in circling (D), head-twitching response (F), and distance traveled (H) in a 5-min time interval after acute saline or β-PEA administration. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. saline control group. SAL, saline; β-PEA, β-phenylethylamine. n = 9 per group.