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. 2021 Aug 31;22(17):9485. doi: 10.3390/ijms22179485

Figure 4.

Figure 4

Effects of β-PEA on self-administration under fixed ratio (FR) schedules of reinforcement in rats. (A) Experimental timeline for β-PEA self-administration. (B–D) Number of infusions (B), active lever (C), and inactive lever (D) pressing responses during 2 h session β-PEA self-administration under FR1 and FR3 schedules. (E–H) Mean number of infusions and drug intake under FR1 (E,F) and FR3 (G,H) schedules of reinforcement. (I) Representative hatch marks indicate the infusion patterns of saline and β-PEA for 2 h at the final self-administration session of the FR3 schedule. (J) Temporal changes in drug infusions at the final self-administration session of the FR3 schedule. *** p < 0.001 vs. saline control group. SAL, saline; β-PEA, β-phenylethylamine, FPT: food training test, CI; catheter implantation. n = 8 per group.