Skip to main content
. 2021 Aug 31;22(17):9501. doi: 10.3390/ijms22179501

Figure 1.

Figure 1

Changes in the composition of the total ICOS+- and ICOS−-Treg/Tresp pools with age in healthy volunteers, SLE patients in remission and SLE patients with active disease. The percentage of RTEs, MNs, CD31+-memory cells and CD31−-memory cells is shown for the ICOS+-Treg Pool (A), the ICOS−-Treg pool (B), the ICOS+-Tresp pool (E) and the ICOS−-Tresp pool (F) in healthy volunteers (Black coloured), SLE patients in remission (Green coloured) and in SLE patients with active disease (Red coloured). The figures present the regression lines concerning the changes in the percentages of the individual Treg/Tresp cell subsets with age. Significant age-dependent changes are marked by black, green, or red P-values. Significant age-independent differences between healthy volunteers and SLE patients in remission or SLE patients with active disease are marked by green or red underlined P-values. Age-independent increased differentiation of ICOS+ and ICOS−- RTE-Tregs/Tresps into CD31−-memory Tregs/Tresps via MN-Tregs/Tresps or CD31+-memory Tregs/Tresp is shown for SLE patients in remission (green arrows) and for SLE patients with active disease (red arrows) (C,D,G,H). Further information of the calculated P-values is illustrated in Table S1.