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Classical Hodgkin Lymphoma, Mixed Cellularity. The lymph node architecture is effaced by a mixed population of lymphocytes, plasma cells, eosinophils, histiocytes and Reed–Sternberg (RS) cells ((A,B), Hematoxilin & eosin, 100× and 400×). RS cells are weakly positive for PAX5 ((C), 200×), and Epstein–Barr encoded RNA (EBERs) can be detected ((D), 200×). CD30 and CD15 are strongly positive in RS cells ((E,F) respectively, 200×).
