Figure 4.

Behavior in DTx-treated mice. (A–C) Travel paths and the times spent in the center compartment and the border compartment in a classical open field test (OFT). The behavior was tested at baseline (0d) and 30d after DTx treatment with 0.1 ng/g/d for 5 consecutive days. Exploration of the center dropped in all mice in the 30 d retest without difference between groups. Each scatter is a mouse, sample size n = 4–6. (D–F) Motor coordination analysis in the pole test and accelerating Rotarod test and body weights at baseline and 30 d after 5 × 0.1 ng/g DTx. Mice were 13–16 weeks old at the onset of DTx. Sample size n = 4–6 per group.