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. 2021 Aug 28;13(17):4353. doi: 10.3390/cancers13174353

Figure 3.

Figure 3

The effects of cannabinoids on CRC. See text for discussion. Created with BioRender.com (accessed on 10 August 2021). Abbreviations: AMPK—AMP kinase; ATF4—activated transcription factor 4; AKT—protein kinase B; CBR—cannabinoid receptor; cdc2—cell division control 2; cAMP PK—cyclic AMP protein kinase; CBD—cannabidiol; CHOP—C/EBP homologous protein; DR5—death receptor 5; eIF2α—eukaryotic initiation factor 2α; ERK1/2—extracellular regulated kinase 1/2; FGF2—fibroblast growth factor 2; GPR55—G protein coupled receptor 55; HIFα—hypoxia inducible factor α; ICAM-1—intercellular adhesion molecule 1; IFN-γ—interferon γ; IL-1—interleukin 1; IL-8—interleukin 8; IL-10—interleukin 10; MAPK—mitogen-activated protein kinase; MMP 9—matrix metalloproteinase 9; STAT-5—signal transducer and activator of transcription 5; mTOR—mammalian target of rapamycin; PDGFA—platelet-derived growth factor A; PGE2—prostaglandin 2; PI3K—phosphoinositide-3 kinase; TNF-α—tumor necrosis factor α; TRAIL—Tumor necrosis factor-related apoptosis-inducing ligand; TRIB3—tribbles homolog 3; VEGF—vascular endothelial growth factor.