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. 2021 Aug 31;22(17):9488. doi: 10.3390/ijms22179488

Figure 1.

Figure 1

Plasmin cleaves transthyretin V30M, and its activity is inhibited by SerpinA1. Representative images of Western blotting analysis of the three independent in vitro experiments. Western blot was performed using two different antibodies targeting human TTR, mouse anti-TTR mutant (Y78F), clone AD7 (A), and rabbit anti-transthyretin (B). Both antibodies detected dimeric and monomeric TTR forms. However, only the mouse anti-TTR mutant (Y78F) clone AD7 detects TTR fragments (A).