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. 2021 Sep 3;22(17):9556. doi: 10.3390/ijms22179556

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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L-sepiapterin impaired cell growth and improved sensitivity to apoptosis of metastatic melanoma cells. 4C11+ metastatic melanoma cells were treated (+) or not (non-treated) (-) with 40 μM L-sepiapterin (L-SEP) and (A) cell viability, (B) clonogenic capability, (C) anoikis resistance, and (D) dacarbazine (DAC) treatment sensitivity were evaluated. WT: wild type 4C11+ metastatic melanoma cell line; TRC1: control non-target shRNA; sheNOS#1 and sheNOS#2: clones silenced for eNOS. Values are reported in the bar graphs and expressed as the means ± S.D. The experiments were performed in triplicate and p values were based on the one-way ANOVA test followed by the Bonferroni post-test or on the two-way ANOVA test followed by Bonferroni post-test; *, p < 0.05; **, p < 0.01; ***, p < 0.001.