Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Overview of the GDEPT approach. Cancer cells are transfected with a construct carrying a suicide gene. Due to transfection, a fraction of cancer cells take up the gene, while other cells remain intact. Expression of the suicide gene within the cancer cells produces an enzyme that converts a prodrug into a toxic drug that leads to cell death. This toxic drug may diffuse into the surrounding cells (bystander effect) and kill them.
