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. 2021 Aug 26;13(17):4316. doi: 10.3390/cancers13174316

Table 1.

Comparison of some specificities of existent risk stratification systems (RSSs). Note: ETE = extra-thyroidal extension; RSS = risk stratification system.

RSS Number
of Classes
Meaning of
TIRADS 1
Pattern or Point-Based RSS Features of High Suspicion Composition Included in the RSS ETE
Included in the RSS
Chilean
TIRADS
6
TIRADS 4 divided into 2 subclasses
Normal examination Pattern Irregular margins
Irregular shape
Multiple peripheral microcalcifications Penetrating vessels
Yes No
Kwak-TIRADS 5
TIRADS 4 divided into 3 subclasses
No nodule Point Marked
hypoechogenicity
Irregular margins Microcalcifications
Taller than wide
No No
BTA 5 Normal Pattern In a solid hypoechoic nodule:
Irregular margins Microcalcifications Globular
calcifications
Intranodular
vascularity
Taller than wide
Lymphadenopathy
Yes No
AACE 3 Low risk Pattern Marked
hypoechogenicity
Irregular margins
Microcalcifications Taller-than-wide
Extrathyroidal growth
Pathologic lymph node.
No Yes
ATA 5 Benign Pattern In a solid hypoechoic nodule:
Irregular margins Microcalcifications
Taller than wide
Rim calcifications with small extrusive soft tissue component
Extra-thyroidal extension
Yes Yes
K-TIRADS 5 Absence of nodule Pattern In a solid hypoechoic nodule:
Irregular margins Microcalcification Nonparallel
orientation
Yes No
EU-TIRADS 5 Absence of significant nodule Pattern Marked
hypoechogenicity
Irregular margins Microcalcifications
Taller than wide
No No
ACR-TIRADS 5 Benign Point Marked
hypoechogenicity
All punctate
echogenic foci
Taller-than-wide
Extra-thyroidal
extension
Yes Yes
C-TIRADS 5
TIRADS 4 divided into 3 subclasses
No nodule Point Markedly
hypoechogenicity
Ill-defined and
irregular margins Vertical orientation
Solid composition Microcalcifications Extra-thyroidal
extension
Yes Yes

For abbreviations of the names of the RSSs, please refer to Section 1.1. Note: ETE = extra-thyroidal extension; RSS = risk stratification system.