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. 2021 Aug 31;18(17):9159. doi: 10.3390/ijerph18179159

Table 2.

The subgroup analysis of the effect of distract intervention on needle-related pain of the child by the study characteristics (N = 41).

Characteristics Subgroup K N Overall ES 95% CI Z (p) I2 (%)
Lower Limit Upper Limit
Age (year) <10 15 1419 0.27 −0.18 0.73 1.17 (0.242) 95.4
≥10 26 1761 −1.07 −1.60 −0.53 −3.92 (<0.001) 85.3
Center One 38 2671 −0.51 −0.85 −0.17 −2.96 (0.003) 92.7
Multi-center 3 509 −0.43 −0.96 0.09 −1.61 (0.108) 0.0
IRB No 4 233 1.97 −4.31 8.25 0.61 (0.539) 98.7
Yes 37 2947 −0.64 −0.89 −0.39 −5.04 (<0.001) 84.9
Fund Yes 15 1340 −0.83 −1.20 −0.46 −4.41 (<0.001) 90.5
No 26 1840 −0.18 −0.84 0.47 −0.55 (0.581) 93.0
Study design RCT 37 2932 −0.61 −0.92 −0.30 −3.85 (<0.001) 91.3
Quasi-E 4 248 0.94 −3.60 5.48 0.40 (0.685) 96.9
Type of intervention Audial 7 394 −0.38 −2.10 1.33 −0.44 (0.661) 94.9
Visual 17 1790 −0.76 −1.15 −0.37 −3.86 (<0.001) 89.6
Clown 2 119 −3.64 −4.76 −2.52 −6.36 (<0.001) 91.9
Cognitive 2 107 −0.47 −1.64 0.70 −0.79 (0.428) 0.0
Multi methods 12 703 0.31 −0.35 0.97 0.92 (0.360) 93.4
Local anesthesia 1 67 0.67
Quality assessment score <10 24 2077 −0.35 −1.16 0.46 −0.84 (0.400) 93.6
≥10 17 1103 −0.65 −0.98 −0.32 −3.84 (<0.001) 89.3

Notes. K: Number of studies, N: Number of participants, ES: Effect size, CI: Confidence interval, IRB: Institutional Review Board, RCT: Randomized controlled trial, Quasi-E: Quasi-experimental design.