Table 2.
Characteristics | Subgroup | K | N | Overall ES | 95% CI | Z (p) | I2 (%) | |
---|---|---|---|---|---|---|---|---|
Lower Limit | Upper Limit | |||||||
Age (year) | <10 | 15 | 1419 | 0.27 | −0.18 | 0.73 | 1.17 (0.242) | 95.4 |
≥10 | 26 | 1761 | −1.07 | −1.60 | −0.53 | −3.92 (<0.001) | 85.3 | |
Center | One | 38 | 2671 | −0.51 | −0.85 | −0.17 | −2.96 (0.003) | 92.7 |
Multi-center | 3 | 509 | −0.43 | −0.96 | 0.09 | −1.61 (0.108) | 0.0 | |
IRB | No | 4 | 233 | 1.97 | −4.31 | 8.25 | 0.61 (0.539) | 98.7 |
Yes | 37 | 2947 | −0.64 | −0.89 | −0.39 | −5.04 (<0.001) | 84.9 | |
Fund | Yes | 15 | 1340 | −0.83 | −1.20 | −0.46 | −4.41 (<0.001) | 90.5 |
No | 26 | 1840 | −0.18 | −0.84 | 0.47 | −0.55 (0.581) | 93.0 | |
Study design | RCT | 37 | 2932 | −0.61 | −0.92 | −0.30 | −3.85 (<0.001) | 91.3 |
Quasi-E | 4 | 248 | 0.94 | −3.60 | 5.48 | 0.40 (0.685) | 96.9 | |
Type of intervention | Audial | 7 | 394 | −0.38 | −2.10 | 1.33 | −0.44 (0.661) | 94.9 |
Visual | 17 | 1790 | −0.76 | −1.15 | −0.37 | −3.86 (<0.001) | 89.6 | |
Clown | 2 | 119 | −3.64 | −4.76 | −2.52 | −6.36 (<0.001) | 91.9 | |
Cognitive | 2 | 107 | −0.47 | −1.64 | 0.70 | −0.79 (0.428) | 0.0 | |
Multi methods | 12 | 703 | 0.31 | −0.35 | 0.97 | 0.92 (0.360) | 93.4 | |
Local anesthesia | 1 | 67 | 0.67 | |||||
Quality assessment score | <10 | 24 | 2077 | −0.35 | −1.16 | 0.46 | −0.84 (0.400) | 93.6 |
≥10 | 17 | 1103 | −0.65 | −0.98 | −0.32 | −3.84 (<0.001) | 89.3 |
Notes. K: Number of studies, N: Number of participants, ES: Effect size, CI: Confidence interval, IRB: Institutional Review Board, RCT: Randomized controlled trial, Quasi-E: Quasi-experimental design.