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. 2021 Aug 30;22(17):9421. doi: 10.3390/ijms22179421

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Myrcene effectively controls UVB-radiated skin aging through MMPs and IL-6 downregulation and collagen synthesis through TGF-β upregulation (Modified from Hwang 2017 [80]). Myrcene not only blocks collagen degradation by protecting UVB-induced ROS but also stimulates collagen synthesis through TGF-β1 activation. UVB-induced ROS finally induces collagen degradation, which is caused by MMP-1, MMP-3, and MMP-9 that are made by transcription factors such as AP-1, cFos, and cJun. UVB radiation inhibits TGF-β1 activation, which stimulates collagen synthesis. : to inhibit the follow action.

Inline graphic — Myrcene effectively controls UVB-radiated skin aging through MMPs and IL-6 downregulation and collagen synthesis through TGF-β upregulation (Modified from Hwang 2017 [80]). Myrcene not only blocks collagen degradation by protecting UVB-induced ROS but also stimulates collagen synthesis through TGF-β1 activation. UVB-induced ROS finally induces collagen degradation, which is caused by MMP-1, MMP-3, and MMP-9 that are made by transcription factors such as AP-1, cFos, and cJun. UVB radiation inhibits TGF-β1 activation, which stimulates collagen synthesis. : to inhibit the follow action.