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(A) Dose response activation of human and mouse PPARα and PPARδ by TIPP-401. (B) Transactivation assay using point mutants of the PPARα LBD. (C) (left) Overall crystal structure of APHM-19 complexed with PPARα LBD. (right) Zoomed view of the Ile272 interaction (hydrophobic tail) with APHM-19.
