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. 2021 Aug 26;22(17):9223. doi: 10.3390/ijms22179223

Figure 11.

Figure 11

(A) Zoomed view of the hydrophobic tail of TIPP-401 complexed with the human PPARα LBD. (B) Structural design of APHM-13. (C) X-ray crystallographic structure of APHM-13 complexed with the human PPARα LBD. (D) Zoomed view of the hydrophobic tail of APHM-13 complexed with the human PPARα LBD. (E) Fluorescence polarization value changes with the addition of human PPARα to APHM-13 in PBS. (F) Fluorescence polarization value changes with the addition of human PPARδ to APHM-13 in PBS. (G) Zoomed view of the hydrophobic interaction of the pyrene ring of APHM-13. (H) Zoomed view of the hydrophobic interaction of the 2-fluoro-4-trifluorophenyl ring of TIPP-401.