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. 2021 Aug 26;22(17):9223. doi: 10.3390/ijms22179223

Figure 19.

Figure 19

(A–G) Crystal structures of hPPARc LBD–MO-4R and hPPARc LBD–MEKT-21 complexes. (A) Structure of the whole hPPARcLBD–MEKT-21 complex. Protein is represented by a blue ribbon model and MEKT-21 is depicted with a magenta cylinder model. The numbering of the second structure is also depicted. The nomenclature of the helices is based on the RXR-α crystal structure. (B) The superimposed structures of MO-4R and MEKT-21 complexed with the hPPARc LBD. (C) Structure of the whole hPPARχ LBD–MO-4R complex. Protein is represented by a white ribbon model and MO-4R is depicted with a green cylinder model. (D) Zoomed view of the binding mode of the hydrophobic tail part of MO-4R in the Y3 arm. The side chains of amino acids of the Y3 arm are depicted by blue cylinder models. (E) Zoomed view of the binding mode of the hydrophobic tail of MEKT-21 in the Y3 arm. (F) Zoomed view of the alignment of the hydrophobic tail of MO-4R and MEKT-21. (G) Image F rotated by 90 degrees.