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. 2021 Aug 26;22(17):9223. doi: 10.3390/ijms22179223

Figure 22.

Figure 22

(AC) Zoomed views of the binding mode of the AF2 region (H12 helix) of hPPARγ LBD–rosiglitazone. (A) Zoomed view of the hPPARγ LBD–rosiglitazone (full agonist) complex. (B) Zoomed view of the hPPARγ LBD–MEKT-21 (partial agonist) complex. (C) Zoomed view of the hPPARγ LBD–N-[1-(4-fluorophenyl)-3-(2-thenyl)-1H-pyrazole-5-yl]-3,5-bis(trifluoromethyl)benzenesulfonamide (partial agonist) complex. (DF) Chemical structures of these agonists. (D) rosiglitazone, (E) MEKT-21, and (F) N-[1-(4-fluorophenyl)-3-(2-thenyl)-1H-pyrazole-5-yl]-3,5-bis(trifluoromethyl)benzenesulfonamide.