Table 2.
Familial risk for index persons whose parents or siblings were diagnosed with concordant cancer.
| Cancer Site | Only Parent Diagnosed with Concordant Cancer | Only Sibling Diagnosed with Concordant Cancer | ||||||
|---|---|---|---|---|---|---|---|---|
| O | SIR | 95% CI | O | SIR | 95% CI | |||
| Lip | 73 | 1.78 | 1.39 | 2.24 | 46 | 2.44 | 1.79 | 3.26 |
| Salivary gland | 3 | 1.80 | 0.34 | 5.34 | ||||
| Pharynx | 15 | 1.66 | 0.93 | 2.75 | 30 | 3.88 | 2.62 | 5.55 |
| Esophagus | 43 | 2.37 | 1.71 | 3.19 | 30 | 2.91 | 1.96 | 4.16 |
| Stomach * | 307 | 1.66 | 1.48 | 1.85 | 94 | 2.74 | 2.22 | 3.36 |
| Small intestine | 31 | 5.37 | 3.65 | 7.63 | 21 | 6.11 | 3.78 | 9.36 |
| Colorectum | 4981 | 1.66 | 1.62 | 1.71 | 2252 | 1.76 | 1.69 | 1.84 |
| Colon | 2249 | 1.79 | 1.71 | 1.86 | 1060 | 1.96 | 1.84 | 2.08 |
| Rectum | 696 | 1.61 | 1.49 | 1.73 | 341 | 1.69 | 1.52 | 1.88 |
| Liver, primary | 56 | 2.30 | 1.73 | 2.98 | 28 | 2.65 | 1.76 | 3.84 |
| Pancreas | 320 | 1.99 | 1.78 | 2.22 | 135 | 2.17 | 1.82 | 2.57 |
| Lung * | 2247 | 1.86 | 1.79 | 1.94 | 1875 | 2.50 | 2.39 | 2.62 |
| Breast | 9154 | 1.74 | 1.70 | 1.77 | 6573 | 1.73 | 1.69 | 1.77 |
| Cervix | 155 | 1.51 | 1.28 | 1.76 | 68 | 1.58 | 1.23 | 2.01 |
| Endometrium | 511 | 1.94 | 1.78 | 2.12 | 288 | 1.82 | 1.61 | 2.04 |
| Ovary | 319 | 2.32 | 2.08 | 2.59 | 162 | 2.31 | 1.97 | 2.70 |
| Prostate * | 11,791 | 2.05 | 2.01 | 2.09 | 9897 | 2.38 | 2.33 | 2.43 |
| Testis | 51 | 4.56 | 3.39 | 5.99 | 107 | 5.56 | 4.55 | 6.72 |
| Kidney | 211 | 1.77 | 1.54 | 2.03 | 108 | 2.38 | 1.95 | 2.87 |
| Bladder | 835 | 1.76 | 1.64 | 1.88 | 459 | 1.94 | 1.77 | 2.12 |
| Melanoma | 1360 | 2.37 | 2.24 | 2.49 | 1260 | 2.45 | 2.32 | 2.59 |
| Skin | 991 | 1.98 | 1.86 | 2.11 | 426 | 1.89 | 1.72 | 2.08 |
| Eye | 8 | 3.30 | 1.41 | 6.53 | 2 | 1.42 | 0.13 | 5.24 |
| Nervous system | 443 | 1.49 | 1.36 | 1.64 | 320 | 1.64 | 1.47 | 1.83 |
| Thyroid gland, adenocarcinoma | 71 | 3.78 | 2.95 | 4.77 | 65 | 4.98 | 3.84 | 6.35 |
| Endocrine glands | 201 | 2.03 | 1.76 | 2.34 | 124 | 2.00 | 1.67 | 2.39 |
| Bone | 5 | 6.11 | 1.93 | 14.36 | 4 | 8.23 | 2.14 | 21.29 |
| Connective tissue | 22 | 1.76 | 1.10 | 2.67 | 10 | 1.61 | 0.77 | 2.97 |
| Hodgkin disease * | 23 | 2.87 | 1.81 | 4.31 | 34 | 6.77 | 4.69 | 9.47 |
| Non-Hodgkin lymphoma | 443 | 1.66 | 1.51 | 1.82 | 294 | 1.80 | 1.60 | 2.02 |
| Myeloma | 96 | 1.92 | 1.56 | 2.35 | 44 | 2.00 | 1.45 | 2.69 |
| Leukemia | 409 | 1.83 | 1.66 | 2.02 | 217 | 1.97 | 1.72 | 2.26 |
| All above * | 38,120 | 1.86 | 1.84 | 1.88 | 26,374 | 2.07 | 2.04 | 2.09 |
O = Observed; SIR = Standardized incidence ratio; CI = Confidence intervals. *: SIRs between cases with parental and sibling probands were significant (non-overlapping 95%CIs).