Table 3.

Concordant familial risks when one or at least two probands were diagnosed with cancer.

Cancer Site	One Family Member Diagnosed with Concordant Cancer				Two or More Family Members Diagnosed with Concordant Cancer
	O	SIR	95% CI		O	SIR	95% CI
Lip	119	2.00	1.66	2.40
Salivary gland	3	1.19	0.22	3.51
Pharynx	45	2.70	1.97	3.62
Esophagus	73	2.59	2.03	3.25
Stomach	401	1.83	1.65	2.01	10	5.55	2.64	10.25
Small intestine	52	5.64	4.21	7.40	2	112.36	10.59	413.21
Colorectum	7233	1.70	1.66	1.74	417	2.76	2.51	3.04
Colon	3309	1.84	1.78	1.90	153	3.64	3.08	4.26
Rectum	1037	1.64	1.54	1.74	17	2.20	1.28	3.52
Liver, primary	84	2.40	1.92	2.98	2	12.57	1.19	46.23
Pancreas	455	2.04	1.86	2.24	10	4.96	2.36	9.15
Lung	4122	2.11	2.05	2.17	169	3.42	2.93	3.98
Breast	15,805	1.74	1.71	1.76	913	2.50	2.34	2.67
Cervix	223	1.54	1.35	1.76
Endometrium	799	1.90	1.77	2.03	22	5.58	3.49	8.46
Ovary	481	2.32	2.12	2.54	14	8.99	4.90	15.13
Prostate	21,688	2.20	2.17	2.23	2550	3.74	3.60	3.89
Testis	158	5.24	4.45	6.12
Kidney parenchyma	319	1.94	1.73	2.16	6	5.17	1.86	11.33
Bladder	1294	1.82	1.72	1.92	25	2.48	1.60	3.67
Melanoma	2620	2.41	2.32	2.50	95	5.68	4.59	6.94
Skin	1417	1.96	1.86	2.06	59	4.60	3.50	5.94
Eye	10	2.62	1.25	4.83
Nervous system	763	1.55	1.44	1.67	27	6.24	4.11	9.09
Thyroid gland, adenomcarcinoma	136	4.33	3.63	5.12
Endocrine glands	325	2.02	1.81	2.26	16	14.82	8.45	24.11
Bone	9	6.93	3.14	13.20
Connective tissue	32	1.71	1.17	2.42	2	55.25	5.21	203.18
Hodgkin disease	57	4.40	3.33	5.71
Non-Hodgkin lymphoma	737	1.71	1.59	1.84	6	1.51	0.54	3.31
Myeloma	140	1.97	1.66	2.32
Leukemia	626	1.88	1.73	2.03	17	5.03	2.92	8.06
All above	64,572	1.94	1.93	1.96	4532	3.33	3.24	3.43

O = Observed; SIR = Standardized incidence ratio; CI = Confidence intervals.