Table 1.
IC50 values of parental and sunitinib-resistant clones c1 and c2 generated from 786-O, A498, and Caki-1 cell lines as measured by MTT assay.
| IC50 Value | ||||
|---|---|---|---|---|
| Cell Line | Biological Replicate | Parental | Clone c1 (p-Value) | Clone c2 (p-Value) |
| 786-O | A | 5.7 | 17.32 | 13.54 |
| B | 11.39 | 23.3 | 20.07 | |
| C | 6.7 | 20.4 | 12.8 | |
| Average | 7.93 | 20.34 ** | 15.47 * | |
| A498 | A | 10.48 | 11.92 | 14.36 |
| B | 7.682 | 12.42 | 16.04 | |
| C | 7.18 | 12.01 | 10.54 | |
| Average | 8.44 | 12.12 * | 13.64 * | |
| Caki-1 | A | 9.5 | 16.8 | 18 |
| B | 9 | 14.6 | 17.3 | |
| C | 12.2 | 16.2 | 14.7 | |
| Average | 10.2 | 15.87 ** | 16.67 * |
Values of biological triplicates are indicated by letters A–C. The dose response curves used to generate the IC50 values can be found in Figures S1–S3. p-values were calculated by an independent t-test and significance denoted by * p < 0.05, ** p < 0.01.