Table 2.

The common inducers and inhibitors of ferroptosis.

Inducer	Class1: Inhibit system Xc- and prevent cystine import	Erastin, Sorafenib, Sulfasalazine
	Class2: Inhibit GPX4	RSL3, (1S,3R)-RSL3, DPI7, DPI10
	Class3: Degrade GPX4, bind to SQS, and deplete antioxidant CoQ10	FIN56
	Class4: Oxidize ferrous iron and lipidome directly, and inactivate GPX4 indirectly	FINO2
	Supplement: Target VDACs, degrade GPX4	Erastin
Inhibitor	Class1: Inhibit accumulation of iron	DFO, Deferoxamine mesylate, 2,2′-pyridine
	Class2: Inhibit lipid peroxidation	Fer-1, SRS11–9, SRS16–86, Liproxststatin-1, Vitamin E

Ac—acetaminophen; ART—artesunate; COQ1—coenzyme Q10; DFO—deferoxamine; Fer-1—Ferrostatin-1; GPX4—glutathione peroxidase 4; GSH—glutathione; RSL3—Ras-selective lethal small molecule 3; VDACs—voltage-dependent anion channels.