TABLE 2.

Target genes that improve virulence by genetic engineering strategies.

Modified gene	Mode of action	Effect	References
Pr1A	Fused CDEP1 with Bbchit1 and Pr1A	LT50 decreased by 25% LC50 decreased by 25%	Fang et al., 2009; Fan et al., 2010
Cyt2Ba	Transformed pBARGPE1-Cyt2Ba into blastospores	Infection rate increased LT50 decreased Reproductive rate decreased	Deng et al., 2019b
TMOF	Introduced Aea-TMOF into B. bassiana	LT50 decreased by 15% LC50 decreased by 40%	Kamareddine et al., 2013
TMOF	Fused CP of TMV with TMOF	LC50 decreased	Borovsky et al., 2006
Spn43Ac	Introduced Spn43Ac of Drosophila into B. bassiana	LT50 decreased by ∼24% LC50 decreased by 300%	Yang et al., 2014