Table 3.
Utilization of HSP70 and HSP90 of host cells by RNA viruses at particular stages of infection.
| Stage of Infection | RNA Virus | HSP70 | HSP90 | References |
|---|---|---|---|---|
| Internalization of the virus into the host cell |
CAV-9 | + | + | [72,73,74,75,76,77,78,79,80] |
| DENV | + | + | ||
| EV-71 | + | + | ||
| JEV | + | nd | ||
| ZIKV | + | nd | ||
| Virus replication | RSV | + | + | [81,82,83,84,85,86,87,88,89,90,91,92,93,94,95] |
| HCV | + | + | ||
| IAV | + | + | ||
| MuV | + | nd | ||
| CDV | + | nd | ||
| EBOV | + | nd | ||
| SARS-CoV-2 | + | nd | ||
| VSV | nd | + | ||
| HPIV-2 | nd | + | ||
| HPIV-3 | nd | + | ||
| SV40 | nd | + | ||
| CHIKV | nd | + | ||
| EV-71 | nd | + | ||
| Protein maturation, formation and virions release |
HCV | nd | + | [96,97,98] |
| Polio | nd | + | ||
| Rhinovirus | nd | + | ||
| Coxsackie | nd | + | ||
| IAV | nd | + | ||
| Virus gene expression | ZIKV | + | nd | [77,99,100] |
| EV-71 | + | nd | ||
| CVB3 | + | nd | ||
| Virus assembly | Polio | + | nd | [101,102,103] |
| CVB1 | + | nd | ||
| IAV | + | nd | ||
| Reovirus | + | nd |
Legend: CAV-9—Coxsackievirus A9; CDV—Canine distemper virus; CHIKV—Chikungunya virus; CVB1—Coxsackievirus B1; CVB3—Coxsackievirus B3; DENV—Dengue virus; EBOV—Ebola virus; EV-71—Enterovirus 71; HCV—Hepatitis C virus; HPIV—human parainfluenza viruses; IAV—Influenza A virus; JEV—Japanese Encephalitis Virus; MuV—Mumps virus; RSV—Respiratory syncytial virus; SARS-CoV-2—severe acute respiratory syndrome coronavirus 2; SV40—Simian virus 40; VSV—Vesicular stomatitis virus; ZIKV—Zika Virus;.+—documented use of the protein by the virus; nd—no data.