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. 2021 Aug 20;12:706772. doi: 10.3389/fmicb.2021.706772

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Copyright © 2021 Wen, Li, Wang, Zhu, Zong, Wang and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in cecal metabolite profile of mice shaped by heat stress. (A) PCA score plot. (B) OPLS-DA score plot. (C) heatmap tree show metabolites significantly different between groups and their phylogenic relationships. (D) Metabolic pathway enrichment analysis. (E) Biomarker analysis. (F) Correlations between serum indicators and gut microbiota, and cecum metabolic indicators mediated by heat stress. CON, control group; HS, heat stress group; OPLS-DA, Orthogonal partial least squares method-discriminant analysis. *P < 0.05, **P < 0.01, ***P < 0.001.