Figure 3.

Kaplan–Meier curves based on pre-NAC MLKL and pre-NAC pMLKL status. (a,b) No significant difference was detected in pre-NAC MLKL status for the 5 year OS and DFS. (c) The 5 year OS tended to be worse in patients with high pMLKL status than in those with low pMLKL, but this difference did not reach statistical significance. (d) No significance was detected in pre-NAC pMLKL status for the 5 year DFS. Abbreviations: MLKL, mixed lineage kinase domain-like protein; pMLKL, phosphorylated MLKL; OS, overall survival; DFS, disease-free survival; NAC, neoadjuvant chemotherapy.