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. 2021 Aug 31;13(17):4392. doi: 10.3390/cancers13174392

Figure 6.

Figure 6

The SSU can be targeted by protein synthesis inhibitors at two main regions. (a) Overview of the binding sites for small molecules binding to the 40S subunit. Amicoumacin A (AMA) in green (PDB: 5I4L), cryptopleurine in salmon (PDB: 4U55), edeine (EDE) in olive green (PDB: 4U4N) and pactamycin (PAC) in ruby (PDB: 4U4Y). mRNA is also shown as a ribbon and coloured in purple. Inhibitors have been shown to bind with high specificity to the mRNA path and the decoding centre (DC), thus impairing tRNA–mRNA translocation and altering the translation fidelity process; (b) zoom-in and details of interaction for EDE within the mRNA path in correspondence with where the E-site tRNA should interact. The clash with mRNA (shown in red) would prevent the formation of the preinitiation complex; (c) zoom-in and details of interaction for AMA within the mRNA path. AMA forms a π–π stacking interaction with the conserved rRNA residue G904 while hydrogen bonding with the conserved A1005 (shown as dashed lines).