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. 2021 Aug 31;22(17):9472. doi: 10.3390/ijms22179472

Table 1.

Components of the ECS and possible targets for the treatment of various diseases.

Endo-Cannabinoids
(“Endogenous Cannabinoids”/
eCBs)		 Enzymes Receptors Transport
Proteins
Synthesizing Degradative
  • -

    2-AG [17]

  • -

    AEA [17]

  • -

    PEA [17]

  • -

    OEA [17]
  • -

    DAGL (2-AG) [18]

  • -

    NAPE-PLD (AEA) [19]
  • -

    FAAH (AEA) [19]

  • -

    NAAA (AEA) [19]

  • -

    ABHD6 and ABHD12 (2-AG) [18]

  • -

    MAGL (2-AG) [18]
  • -

    CB1R/CB2R

  • -

    (2-AG and AEA)

  • -

    GPR18 [20]

  • -

    GPR55 [21,22],

  • -

    GPR119 [23],

  • -

    TRPV1 (AEA) [24]

  • -

    PPARγ [15]
  • -

    FABPs [25,26]

  • -

    HSP70s [27]

  • -

    Serum albumin [27]

  • -

    FAAH-like AEA transporter (FLAT) [28]

  • -

    AMT aka EMT [19,29,30].