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. 2021 Aug 31;22(17):9472. doi: 10.3390/ijms22179472

Table 7.

Examples of peripheral CB1R agonists (aka peripherally restricted cannabinoid 1 receptor (PRCB)) and their therapeutic window.

Peripheral CB1R Agonists
(Aka Peripherally Restricted Cannabinoid 1 Receptor (PRCB))		 Biological Effect(s) and/or Mechanism of Action Reference
i. 4-{2-[-(1E)-1[(4-propylnaphthalen-1-yl)methylidene]-1H-inden-3-yl]ethyl}morpholine (“PrNMI” aka 2-“5u”
  • -

    Anti-allodynic properties (suppresses CIPN* mechanical and cold allodynia in a dose-dependent way). *Chemotherapy-induced peripheral neuropathy (CIPN)

  • -

    Alleviation of cancer-induced bone pain (CIBP)

  • -

    Neuropathic pain

 [87,345,346]
ii. 4-{2-[(1E)-1-[(4-Methoxynaphthalen-1-yl)methylidene]-1H-inden-3-yl]ethyl}morpholine (2-5j)
  • -

    Anti-allodynic properties (suppresses mechanical allodynia symptoms

 [346]
iii. 2-5j (2-5j)
  • -

    Anti-allodynic properties (suppresses mechanical allodynia symptoms

 [346]