Skip to main content
. 2021 Aug 31;22(17):9472. doi: 10.3390/ijms22179472

Table 8.

Examples of peripheral CB2R agonists and their therapeutic windows.

CB2R Agonists Biological Effect(s) and/or Mechanism of Action Reference
i. AM1241 (University of Connecticut)
  • -

    Analgesic

  • -

    Anti-inflammatory

  • -

    Reduction in bone resorption (loss) in NCTC-2472 bone sarcoma cell line

  • -

    Attenuation of spontaneous and evoked pain in tumour-bearing limb

  • -

    Reduction in cancer-induced pain

  • -

    Neuropathic pain

 [136,347,348,349,350,351]
ii. A-76260
  • -

    Analgesic in murine model

 [352]
iii. HU-308 (Hebrew University)
  • -

    Neuropathic pain

  • -

    Anti-inflammatory

  • -

    Analgesic

  • -

    Osteoprotective

  • -

    Prohomeostatic

 [353,354,355]
iv. GSK554418A Acute/chronic pain [356]
v. GW842166X Inflammatory pain [357]
vi. GW405833
  • -

    Anti-inflammatory

  • -

    Suppresses neuropathic pain

 [358]
vii. GP1a
  • -

    Anti-depressant

  • -

    Decreased severity in experimental cystitis

  • -

    Antiallodynic effects in animals on retrovirus infection-induced neuropathic pain

  • -

    Modulation of HIV-1-associated neurocognitive disorders (HAND)

 [359,360,361]
viii. JWH015
  • -

    Antiallodynic effects in animals on retrovirus infection-induced neuropathic pain

  • -

    Attenuates bone cancer pain

  • -

    Anti-inflammatory

  • -

    Immunosuppressive

  • -

    Anti-obesity

 [198,360,361,362,363,364,365]
ix. JWH133
  • -

    Antiallodynic effects in animals on retrovirus infection-induced neuropathic pain

  • -

    Alleviates fibrosis in murine model

  • -

    Anti-inflammatory

  • -

    Anti-proliferative and anti-angiogenic in non-small lung cancer cells (A549) and human umbilical vein endothelial cells.

  • -

    Cardioprotective against ischemia/reperfusion-induced apoptosis

  • -

    Reduces neurodegeneration, neuroinflammation, and spatial memory impairment in Alzheimer’s disease model

  • -

    Anti-nociceptive

 [360]
[366,367,368,369,370]